Dr. James Luccarelli was born and raised in New York City before attending Yale College, where he fell in love with organic chemistry. He pursued a doctorate in chemistry at the University of Oxford on a Marshall Scholarship, before moving to Harvard Medical School. He completed psychiatry residency and child and adolescent psychiatry fellowship at the Massachusetts General Hospital/McLean Hospital program. Since 2022 Dr. Luccarelli has been a faculty member in the department of psychiatry at MGH. His clinical work focuses on the treatment of pediatric patients with severe and treatment-resistant mental illnesses, in particular using neuromodulation techniques especially electroconvulsive therapy. As a researcher his work focuses on leverage “big data” approaches to better characterize the effectiveness of present treatments and identify clinical predictors of response. During the award period his research will focus on predictors of response to electroconvulsive therapy—still the most effective treatment for depression ever invented—as well as characterizing the clinical course of the neuropsychiatric disorder catatonia.